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The Matrixyl® Range

Welcome to the award-winning range of high-tech anti-wrinkle ingredients, from the anti-ageing active ingredient experts.
background  of a 3d illustration of molecule model.

What is Matrixyl?

Matrixyl is a range of active ingredients that mirror the natural process of skin regeneration. These biomimetic peptides stimulate the production of skin components like collagen, elastin and hyaluronic acid, resulting in scientifically proven anti-ageing effects.

Croda Beauty Actives (then known as Sederma) launched the world’s first Matrikine® (extracellular matrix-derived peptide) dedicated to anti-wrinkle in 2000. We called it Matrixyl.

We now have 4 peptides in the Matrixyl range with several versions according to formulation and CSR needs.

All Matrixyl ingredients have been through rigorous testing on skin cells in the lab and in safe clinical studies on hundreds of volunteers.

These extensive tests allow our scientists to accurately determine how the Matrixyl range of peptides work and to clearly show the visible anti-ageing benefits they deliver.

Trust in Matrixyl

Hear what scientists, dermatologists and consumers have to say about award-winning Matrixyl

Independent research shows Matrixyl works

‘Our research, shows that products with Matrixyl will have skin-care benefits.’

Professor Ian Hamley, from the University of Reading's Department of Chemistry

During their studies, the University of Reading researchers measured the effectiveness of Matrixyl on collagen. They found that Matrixyl can almost double the amount of collagen that the cells in our body produce, provided the concentration is high enough.

The research that produced the results above was supported by a university studentship with additional funding by the Engineering and Physical Sciences Research Council (EPSRC).

 You can read the whole research paper on the efficacy of Matrixyl

MATRIKINES, the key to anti-ageing

In 1999, the French Professor, François-Xavier Maquart and his team published their first article mentioning Matrikine (1) .

Matrikines are peptides, derived from the surrounding extracellular matrix. These particular peptides act like messengers to other cells, that start the repair process within the tissue matrix, hence the name.

When a Matrikine peptide is recognised by a cell membrane receptor and binds to that receptor, it triggers intracellular action that:

  • Promotes tissue repair
  • Helps with wound healing
  • Stimulates macromolecule synthesis

Since 1999, a huge number of different Matrikines have been identified. Some with very specialised functions like the stimulation of collagen and fibronectin synthesis in the skin.

These are the kind of peptides Sederma has been developing for their anti-ageing properties. It’s these Matrikines you’ll find in the Matrixyl range

(1) MAQUART FX. et al, 1999, Régulation de l’activité cellulaire par la matrice extracellulaire : le concept de Matrikines, Journal de la Société de Biologie, 193, (4), p 423.

Five benefits of Matrixyl

Trusted by thousands of cosmetic professionals and consumers worldwide, Matrixyl is safe, reliable and it works.