Our peptide journey

Maquart et al. discovered that the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu² stimulates collagen synthesis in fibroblast cultures.

The outbreak of Bovine Spongiform Encephalopathy (BSE), or “mad cow disease,” sparked worldwide health concerns and triggered a shift in cosmetics, with many animal-derived ingredients being replaced by safer alternatives.

Croda Beauty Actives (then known as Sederma) introduced the first palmitoylated peptides, biomimetic Biopeptide CL (collagen fragment) and Biopeptide EL (elastin fragment), marking a breakthrough in peptide technology.

Katayama et al. identified a pentapeptide from type I procollagen that promotes extracellular matrix production.

Matrikines are peptides derived from the extracellular matrix. They act as messengers to surrounding cells, triggering the repair processes within the tissue matrix which is how they get their name.

Since 2000, cosmetic activities have expanded to address a wide range of needs, including:
Firmness • Lifting • Eye & Lash Care • Lip Care • Hair Growth • Stretch Marks • Brightening • Tanning • Peeling • Detox • Hydration • Slimming • Anti-Cellulite

Croda Beauty Actives (then known as Sederma) launched the world’s first Matrikine® (extracellular matrix-derived peptide) dedicated to anti-wrinkle in 2000. We called it Matrixyl®.

Matrikines anti-wrinkle synergistic complex helps reverse the chronological ageing as attested by the regulation of senescence markers and reduce the cutaneous photo damage by restructuring the fragile network of the papillary dermis.

It is the first synergistic association of hero peptide and ceramide for hybrid anti-ageing make-up applications

It is the first minoxidil comparable hair anchorage matrikine and phytoregulators synergistic association for men and women hair anti-ageing.

launch of Matrixyl® synthe’6®,  powerful anti–wrinkle peptide acting on 6 skin–rebuilding essentials and successfully tested on the forehead.

Winner of the “25 Years of Innovation Award” in 2015, Matrixyl was the first mimetic peptide used for personal care applications. It was recognized by peers as a breakthrough in the cosmetic industry then and it’s still a world leader today.

Matrixyl® Morphomics® is the first peptide with side chain expansion, featuring cyclic structures similar to cross-linked collagen.

PoreTect® is the first natural peptide with defined composition.

Crystalide® is a vectorised peptide that allow controlled release into the epidermis, it has won the PCHi Fountain Award for moisturising / hydration active ingredient and Ringier Technology Innovation Award in Skin Care category

Synchrolife™, is the first synergistic combination of peptide and a plant extract, specifically developed to protect skin from blue light damage

Introduction of a biomimetic matrikine protecting follicles and re-educates hair bulbs to produce the original colour of the hair, limiting greying with up to 4 months remanent benefits.

BB-Biont™ is the first peptide developed to rebalance the skin holobionte.

It has been recognized multiple times for its innovation and impact in the cosmetics industry:
2022: I FEEL GOOD award Innovation
2022: Indonesia Cosmetic Ingredients (ICI) Diamond Award
2023: PCHI Fountain Award in Skin Microbiome

KeraBio™ K31 is our first peptide obtained through synthetic biology for hair care, it is a biomimetic bond builder for molecular hair repair.

Introduction of GAP-PS technology for advanced peptide delivery.